CDC Study – Perchlorate exposure from infant formula and comparisons with the perchlorate reference dose.
May 4, 2010 by Chemista
Posted in CDC Information, Critical Health Information, Perchlorate | 1 Comment
One Response
Leave a Reply Cancel reply
Categories
- 9/11 First Responders
- Air Pollution
- Aluminum
- American Petroleum Institute Directives for Bush Administration
- ATSDR
- Autism & Alzheimer's
- Biology
- Bioweapons
- Birth Defects
- Blitzed: Drugs in the Third Reich
- Books
- Bromide
- Burn Pits
- Cadmium
- Cancer Awareness Begins Here
- Cancers from Chromosomal Damage
- CDC Information
- Chemical Manufacturers Association War Declaration against U.S. Regulations
- Chemicals & Chemical Groups
- 2'4-D
- 3M
- An introduction to chemicals
- Asbestos
- Atrazine
- Benomyl
- Benzene
- Benzene Hexachloride
- Benzo[a]pyrene
- Bisphenol A (BPA)
- Chlorinated Hydrocarbons
- Chlorine
- chlorocarbons (organochlorides)
- Chloroform
- DBCP
- Diethylstilbestrol (DES)
- Dioxin
- Dispersants – Corexit EC9500A & EC9529A
- Flame Retardants
- Fluoride
- Glyphosate
- Hexavalent Chromium
- High Fructose Corn Syrup
- hydrofluosilicic acid
- Lead
- Marijuana/Cannabis
- Mustard Gas
- Nanoparticles
- Natural Gas
- nonylphenol
- Organic Phosphates
- PBB
- Perchlorate
- Permethrin
- PFOA
- PFOA/perfluorooctanoic acid
- PFOS
- Plant Estrogens
- polychlorinated aromatic hydrocarbons
- Polychlorinated Biphenyls (PCBs)
- polycyclic aromatic hydrocarbons
- rBST bovine somatotropin (Posilac)
- Sarin
- sodium chloride
- Synthetic Hormones
- Synthetic Vitamin A/ Reinoic acid
- Thalidomide/Contergan
- Trasylol
- Trichloroethene
- Trihalomethanes
- Viagra
- Vinclozolin (Fungicide)
- Vinyl Chloride
- Weapons
- Zonyl & PFOA
- CIA
- Coal Ash
- Cobalt
- Consumer & Parent Resources
- Corporations
- Astra Zeneca
- Bayer (IG Farben)
- Beatrice Foods
- BP Products – British Petroleum
- Bristol-Meyers Squibb
- Carnegie
- Chevron/Texaco
- Dow Chemical
- DuPont
- Eli Lilly/Elanco
- Etablissements Kuklmann
- Exxon
- General Electric
- GlaxoSmithKline
- Imperial Chemical Industries
- Johnson & Johnson
- Koch Industries
- Merck
- Mergers & Corporate Geneology
- Monsanto
- Omnicare
- Rockefeller
- Scovill-Schrader
- Syngenta
- Teva Pharmaceuticals
- United Fruit/Dole
- W.R. Grace
- Critical Health Information
- Critical Information Sites Regarding Toxins Where You Live
- Crude Health Hazards
- Dementia
- Democracy & Civics
- Depro-Provera
- Documentaries
- DOJ Cases, Criminal Verdicts & Fines
- Down Syndrome
- Endocrine Disruption
- Energy Policy
- Energy Task Force
- EPA
- Epigenetics
- European Union
- Evolution
- FDA Investigations & Reports
- General
- Genetics
- Government Investigations
- Green Chemistry
- Hitler's Chemists
- House of Representatives Committee on Oversight and Government Reform Investigations
- IG Farben Doctors
- Infant Leukemia
- IVF
- Judicial System
- Lobbying & Influence
- Media Investigations & Reports
- Merck
- Mirena
- Multiple Sclerosis
- Munitions
- Nanomaterials
- Nanotechnology
- National Cancer Institute & American Cancer Society
- Natural Gas
- Nazi Germany
- Norplant
- Organizations Providing Critical Information
- OSHA
- Parkinsons
- Perfluorinated compounds
- Pfizer
- Pharmaceutical Excipients
- Phytoestrogens
- Politics and policy
- Precautionary Principle
- Preventive medicine
- Radium
- REACH
- Required reading
- Resources & Information for Gulf Residents & Workers impacted by the Oil Spill
- Settlements
- Standard Oil
- Sullivan and Cromwell
- Superfund
- The Energy & Synthetic Chemical Link
- The Silent War – It's Time To Fight Back!
- The Story of Stuff Projects
- Toxins
- Trafficking Markets
- Turner's Syndrome
- Uncategorized
- Understanding Synthetic Chemicals
- VA Agent Orange
- Veterans Affairs
- Water
Pages
Meta
CDC Study – Perchlorate exposure from infant formula and comparisons with the perchlorate reference dose.
J Expo Sci Environ Epidemiol. 2010 May;20(3):281-7. Epub 2009 Mar 18.
Perchlorate exposure from infant formula and comparisons with the perchlorate reference dose.
Schier JG, Wolkin AF, Valentin-Blasini L, Belson MG, Kieszak SM, Rubin CS, Blount BC.
Division of Environmental Hazards and Health Effects, National Center for Environmental Health, Centers for Disease Control and Prevention, Atlanta, Georgia 30341, USA. jschier@cdc.gov
ABSTRACT
Perchlorate exposure may be higher in infants compared with older persons, due to diet (infant formula) and body weight versus intake considerations. Our primary objective was to quantitatively assess perchlorate concentrations in commercially available powdered infant formulas (PIFs). Secondary objectives were: (1) to estimate exposure in infants under different dosing scenarios and compare them with the perchlorate reference dose (RfD); (2) estimate the perchlorate concentration in water used for preparing PIFs that would result in a dose exceeding the RfD; and (3) estimate iodine intakes from PIFs. We quantified perchlorate levels in three samples (different lot numbers) of reconstituted PIF (using perchlorate-free water) from commercial brands of PIF in each of the following categories: bovine milk-based with lactose, soy-based, bovine milk-based but lactose-free, and elemental (typically consisting of synthetic amino acids). Exposure modeling was conducted to determine whether the RfD might be exceeded in 48 dosing scenarios that were dependent on age, centile energy intake per unit of body weight, body weight percentile, and PIF perchlorate concentration. We obtained three different samples in each of the five brands of bovine- and soy-based PIF, three different samples in each of the three brands of lactose-free PIF, and three different samples in two brands of elemental PIF. The results were as follows: bovine milk-based with lactose (1.72 microg/l, range: 0.68-5.05); soy-based (0.21 microg/l, range: 0.10-0.44); lactose-free (0.27 microg/l, range: 0.03-0.93); and elemental (0.18 microg/l, range: 0.08-0.4). Bovine milk-based PIFs with lactose had a significantly higher concentration of perchlorate (P<0.05) compared with all. Perchlorate was a contaminant of all commercially available PIFs tested. Bovine milk-based PIFs with lactose had a significantly higher perchlorate concentration perchlorate than soy, lactose-free, and elemental PIFs. The perchlorate RfD may be exceeded when certain bovine milk-based PIFs are ingested and/or when PIFs are reconstituted with perchlorate-contaminated water.
You can locate more information at pubmed.gov
http://www.ncbi.nlm.nih.gov/pubmed/19293845?itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum&ordinalpos=1