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Nazi biochemical weapon history is very important and it’s still relevant knowledge explaining war today. Two important books on the topic are “Operation Paperclip” by Annie Jacobson and “The Devils Chemists: 24 Conspirators of the International Farben Cartel Who Manufacture Wars” by Nuremberg prosecutor, Josiah E. DuBois, Jr.. “Ghost Map” covers the origins of epidemiology and the nature of Vibrio cholerae. These books provide much enlightenment into warfare strategies and the biological technologies utilized by nations in war. “Medical Apartheid,” by Harriet A. Washington provided the last important piece in the puzzle of the war on Yemen. The information in these books explain the strategic model utilized to destroy nations and someday soon it might be your nation that’s next.

I examine world events closely because of the knowledge I’ve acquired from much of my reading. Hitler’s Director of Chemical Weapons was also IG Farben’s Director of Chemical Operations. Otto Ambros only served 3 years for his mass murder and slavery conviction at Nuremberg. Himmler worked for Ambros, not Hitler, and that’s an important understanding. Both were students of Otto’s father and had been friends since childhood. Otto’s father was a professor of agricultural chemistry. Himmler was originally employed in fertilizing manufacturing prior to his position in the Nazi Party.

Here is an example of how Himmler worked for Ambros and not the other way around.

“The concentration camp already existing with approximately 7000 prisoners is to be expanded.” Santo noted in his official company report. For Ambros, Farben’s arrangement with the SS regarding slave laborers remained vague; Ambros sought clarity. “It is therefore necessary to open negotiations with the Reich Leader SS [Himmler] as soon as possible to discuss necessary measures with him,” Ambros wrote in his official company report. The two men had a decades-old relationship; Heinrich Himmler and Otto Ambros had known one another since grade school. Ambros could make Himmler see eye-to-eye with him on the benefits that Auschwitz offered to both Farben and the SS. – Operation Paperclip. page 153.
Himmler hanged as Ambros advanced and expanded his program and technologies to the industrial combines in NATO nations. Keep this passage with that knowledge in mind.

“Himmler…, the Reichsfuhrer-SS had studied agriculture in school. According to Blome, it was Himmler who was the primary motivator behind the Reich’s bioweapons program. Hitler, Blome said, did not approve of biological warfare and was kept in the dark as to specific plans. Himmler’s area of greatest fascination, said Blome, was bubonic plague.

On April 30, 1943, Goring had created the cancer research post that was to be held by Blome. Over the next nineteen months, Blome explained, he met with Himmler five times.

At their first meeting, which occurred in the summer of 1943—Blome recalled it as being July or August—Himmler ordered Blome to study various dissemination methods of plague bacteria for offensive warfare. According to Blome, he shared with Himmler his fears regarding the dangerous boomerang effect a plague bomb would most likely have on Germany. Himmler told Blome that in that case, he should get to work immediately to produce a vaccine to prevent such a thing. To expedite vaccine research, Blome said, Himmler ordered him “to use human beings.”

Himmler offered Blome a medical block at a concentration camp like Dachau where he could complete this work. Blome said he told Himmler he was aware of “strong objections in certain circles” to using humans in experimental vaccine trials. Himmler told Blome that experimenting on humans was necessary in the war effort. To refuse was “the equivalent of treason.”….

“We know [that] from antiquity up till the time of [the] Napoleonic wars, victories and defeats were often determined by epidemics and starvation.” Blome said. Spreading an infectious disease could bring about the demise of a marauding army, and Blome said that the failure of Napoleon’s Russian campaign was “due in great part to the infection of his horses with Glanders.” a highly contagious bacterial disease. History aside, Blome said he counseled Himmler on the fact that a concentration camp was a terrible place to experiment with bubonic plague because the population was too dense.

Blome then told Himmler that if he were to experiment with plague bacterium, he would need his own institute, an isolated facility far removed from population centers. Himmler and Blame agreed that Poland would be a good place, and they settled on Neseltedt, a small town outside the former Poznan University (by then operated by the Reich) Blome’s research institute was to be called the Bacteriological Institute at Nesselstedt….

Himmler proposed another idea: How about disseminating a virulent strain of hoof-and-mouth disease” Or tularemia, also called rabbit fever, which affected man in a manner similar to plague? Blome told Himmler that these were dangerous ideas, as to any outbreak would surely affect Germany’s troops. The Reich needed a massive stockpile of vaccinations before it could feasibly launch a biological attack.

Himmler stretched his thinking to target Allies on their own soil. How about spreading cattle plague, also called rinderpest, in America or England? Himmler told Blome that infecting the enemy’s food supply would have a sinister effect on enemy troops. Blome agreed and said he would investigate what it wold take to start a plague epidemic among the enemies’ cows. There was, however, a problem, Blome explained. An international agreement prohibited stocks of the rinderpest virus to be stored anywhere in Europe. Strains of cattle plague were available only in the third world.

Himmler said that he would get the cattle plague himself. He sent Dr. Erich Traub, a veterinarian from Reich’s State Research Institute, located on the island of Reims, to Turkey. There, Dr. Traub acquired a strain of the lethal rinderpest virus. Under Blome’s direction, trials to infect healthy cows with rinderpest began….

“Everyone was astounded, ” Schrader told Tilley. This was the most promising chemical killer since the Germans invented mustard gas. Preparation 9/91 was classified as top secret and given a code name: tabun gas. It came from the English word “taboo,” something prohibited or forbidden… At the Dustbin interrogation center, Major Tilley asked Schrader about full-scale production. Based on the Allies’ discovery of thousands of tons of tabun bombs in the forests outside Raubkammer, Farben must have had an enormous secret production facility somewhere. Dr. Schrader said that he was not involved in full-scale production. That was the job of his colleague, Dr. Otto Ambros….

Krauch also revealed a new piece of evidence. Dyhernfurth produced a second nerve agent, one that was even more potent than tabun, called sarin. Sarin was an acronym pieced together from the names of four key persons involved in its development: Schrader and Ambros from IG Farben and from the German Army, two officers named Rudiger and Linde.”- Operation Paperclip: The Secret Intelligence Program That Brought Nazi Scientists to America by Annie Jacobson (Portions from pages 146 -149 & pages 160 – 163)

“We know [that] from antiquity up till the time of [the] Napoleonic wars, victories and defeats were often determined by epidemics and starvation.” Blome said.

Pay close attention to international munition sales.

“The U.S. Senate on Wednesday blocked a bipartisan initiative to suspend a $1.15 billion arms deal to Saudi Arabia, clearing the way for a massive resupply of the Kingdom’s military as it continues its incursions into neighboring Yemen. The victory over lawmakers who were trying to stop the deal will benefit General Dynamics — a defense contractor whose employees and corporate executives have spent millions of dollars on lobbying and campaign contributions in the lead-up to the vote.”

http://www.ibtimes.com/political-capital/saudi-arms-deal-backed-us-senators-who-got-cash-weapons-contractor-will-benefit

Bombing agricultural regions leads to massive starvation in Yemen.

“Martha Mundy, emeritus professor at the London School of Economics, who is currently working in Lebanon with her colleague Cynthia Gharios, has been researching through Yemeni agriculture ministry statistics and says that the data “is beginning to show that in some regions, the Saudis are deliberately striking at agricultural infrastructure in order to destroy the civil society”.
http://www.counterpunch.org/2016/10/27/is-yemen-too-much-for-the-world-to-take/

“The United Nations says the cholera outbreak in war-torn Yemen has now spread to all 21 governorates.”
https://m.medicalxpress.com/news/2017-07-cholera-outbreak-yemen-dead.html

The UN suspended Plan for Cholera Vaccination in Yemen.

“While the latest figures confirmed over 320,000 cases of cholera in Yemen, the World Health Organization announced that it would be canceling the planned shipment of nearly one million cholera vaccines”
http://www.telesurtv.net/english/news/WHO-Cancels-Shipment-of-500000-Cholera-Vaccines-to-Yemen-20170713-0005.html

Yemen’s fast epidemic should alarm anyone with knowledge of Vibrio cholerae . The cholera epidemic in London in 1854 gave birth to epidemiology. It was the first time disease victims were tracked and mapped so Dr. John Snow could discover the origins of the epidemic. His map lead him to the Broad Street Pump and the London cholera epidemic ended when they removed the pump handle.
“Ghost Map.” (London had no infrastructure at that time.) “In the 1851 census, London had a population of 2.4 million… But without infrastructure, two million people suddenly forced to share ninety square miles of space wasn’t just a disaster waiting to happen — it was a kind of permanent, rolling disaster, a vast organism destroying itself by laying waste to its habitat…”
The epidemic of 1854 occurred in only one location in the densely populated London. Yemen’s epidemic is impacting all of her 21 governorates?
Ghost Map’s information is important for understanding the nature of Vibrio cholerae (Cholera).

“The technical name for Cholera Bacterium is Vibrio cholerae. Viewed through the electron microscope, the bacterium looks somewhat like a swimming peanut—a curved rod with a thin, rotating tail called a flagellum that propels the organism, not unlike the outboard motor of a speedboat. On its own, a single V. cholerae bacterium is harmless to humans. You need somewhere between 1 million and 100 million organisms, depending on the acidity of your stomach, to contract the disease. Because our minds have a difficult time grasping the scale of life in the microcosmos of bacterial existence, 100 million microbes sounds, intuitively, like a quantity that would be difficult to ingest accidentally. But it takes about 10 million bacteria per milliliter of water for the organism’s presence be detectable to the human eye. (A milliliter is roughly 0.4 percent—four thousandths—of 1 cup.) A glass of water could easily contain 200 million V. cholerae without the slightest hint of cloudiness.

For those bacteria to pose any threat, you need to ingest the little creatures: simple physical contact can’t get you sick. V. cholerae needs to find its way into your small intestine. At that point, it launches a two-pronged attack. First, a protein called TCP pili helps the bacteria reproduce at an astonishing clip, cementing the organisms into a dense mat, made up of the small intestine’s primary metabolic roles, which is to maintain the body’s overall water balance. The walls of the small intestine are lined with two types of cells: cells that absorb water and pass it on to the rest of the body, and cells that secrete water that ultimately gets flushed out as waste. In a healthy, hydrated body, the small intestine absorbs more water that it secretes, but an invasion of V. cholerae reverses that balance: the cholera toxin tricks the cells into expelling water at a prodigious rate, so much so that in extreme cases people have been known to lose up to thirty percent of body weight in a matter of hours. (Some say that the name cholera itself derives from the Greek word for “roof gutter,” invoking the torrents of water that flow out after a rainstorm.) The expelled fluids contain flakes from the epithelial cells of the small intestine (the white particles that inspired the “rice water” description). They also contain a massive quantity of V. cholerae. An attack of cholera can result in the expulsion of up to twenty liters of fluid, with a per milliliter concentration of V. cholerae of about a hundred million.

In other words, an accidental ingestion of a million Vibrio cholerae can produce a trillion new bacteria over the course of three or four days. The organism effectively converts the human body into a factory for multiplying itself a millionfold. And if the factory doesn’t survive longer than a few days, so be it. There’s usually another one nearby to colonize.

The actual cause of death with cholera is difficult to pinpoint; the human body’s dependence on water is so profound that almost all the major systems begin to fail when so much fluid is evacuated in such a short period of time. Dying of dehydration is, in a sense, an abomination against the very origins of life on earth. Our ancestors evolved first in the oceans of the young planet, and while some organisms managed to adapt to life on the land, our bodies retain a genetic memory of their watery origin. Fertilization for all animals takes place in some form of water: embryos float in the womb; human blood almost has the same concentration of salts as seawater. “Those animal species that fully adapted to the land did so through the trick of taking their former environment with them,” the evolutionary biologist Lynn Margulis writes. “No animal has ever really left the watery microcosm… No matter how high and dry the mountain top, no matter how secluded and modern the retreat, we sweat and cry what is basically seawater.” – Ghost Map (pages 36 – 37)

“We know [that] from antiquity up till the time of [the] Napoleonic wars, victories and defeats were often determined by epidemics and starvation.” Blome said.

Now they are manufacturing both starvation and the epidemics to destroy nations. They are exterminating Yemen in yet another Holocaust and the United States remains silent and enables yet again.

Where did Ambros go to work after his three year prison sentence for his mass murder slavery conviction at Nuremberg?

“On July 28, 1945, Dr. Hirschkind met with Ambros and Lieutenant Colonel Tarr in Heidelberg. Ambros brought his wartime deputy with him to the meeting, the Farben chemist Jurgen von Klenck. It was von Klenck who, in the final months of the war, had helped Ambros destroy evidence, hide documents, and disguise the Farben factory in Gendorf so that it appeared to produce soap, not chemical weapons. Jurgen von Klenck was initially detained at Dustbin but later released. The Heidelberg meetings lasted several days. When Dr. Wilhelm Hirschkind left, he had these words for Ambros: “I would look forward after the conclusion of the peace treaty [to] continuing our relations [in my position] as a representative of Dow.”

Only later did FIAT interrogators learn about this meeting. Major Tilley’s suspicions were now confirmed. A group inside the U.S. Chemical Warfare Service, including his former partner, Lieutenant Colonel Tarr, did indeed have an ulterior motive that ran counter to the motives of CIOS, FIAT, and the United Nations War Crimes Commission. Tilley’s superior at Dustbin, Major Wilson, confirmed this dark and disturbing truth in a classified military intelligence report on the Ambros affair. “It is believed that the conflict between FIAT… and LT-Col Tarr was due to the latter’s wish to use Ambros for industrial chemical purposes” back in the United States.”

“All documents regarding the Ambros affair would remain classified for the next forty years, until August of 1985. That an officer of the U.S. Chemical Warfare Service, Lieutenant Colonel Tarr, had sheltered a wanted war criminal from capture in the aftermath of the German surrender was damning. That this officer was also participating in meetings with the fugitive and a representative from the Dow Chemical Company was scandalous.” – Operation Paperclip (portions from pages 157 – 159)

“In separate letters to Finance Minister Ludger Westrick and Deputy Finance Minister Dr. Dollinger, a new secret was revealed, though Ambros promised not to make public a piece of the information they shared. “Concerning the firms abroad where I am a permanent co-worker advisor,” Ambros wrote, “I won’t name them [publicly] because I don’t want to tip off any journalists who might cause trouble with my friends. You know about W.R. Grace in New York… and I hope I can stay with Hibernia Company. Concerning the firms in Israel,” Ambros wrote, “stating their names publicly would be very embarrassing because they are [run by] very public, well-respected persons in public positions that have actually been at my home and are aware of my position, how I behaved during the Reich, and they accept this.”

The “well-respected” public figures in Israel to whom Ambros referred have never been revealed. That Ambros also had worked for the American company W.R Grace would take decades to come to light. When it did, in the early 1980s, the public would also learn that Otto Ambros worked as a consultant for the U.S. Department of Energy, formerly the Atomic Energy Commission, “to develop and operate a plant for the hydrogenation of coal in a scale of 4 million tons/year at the former IG Farben industry.” That a convicted war criminal had been hired by the Department of Energy sparked indignation, and congressmen and journalists sought further details about Ambros’s U.S. government contract. In a statement to the press, the Department of Energy insisted that the paperwork had been lost…
Letters on White House stationary reveal that Deputy National Security Adviser James W. Nance briefed Reagan about how it was that the U.S. government could have hired Otto Ambros. Nance’s argument to the president was that many others hired him. “Dr. Ambros had contracts with numerous officials from Allied countries,” wrote Nance. “Dr. Ambros was a consultant to companies such as Distillers Limited of England; Pechiney, the French chemical giant; and Dow Europe of Switzerland. He was also the chairman of Knoll, a pharmaceutical subsidiary of the well known chemical corporation BASF.” President Reagan requested further information from the Department of Energy on its Ambros contract. Nance told the president, “The DOE and/or ERDA [The Energy Research and Development Administration] do not have records that would answer the questions you asked in the detail you requested. However, with Ambros’ involvement in the company shown and his special knowledge in hydrogenation of coal, we know there were productive contacts between Dr. Ambros and U.S. energy officials.” Even the president of the United States could not get complete information about an Operation Paperclip legacy.

In the midst of the scandal, a reporter for the San Francisco Chronicle telephoned Ambros at his home in Mannheim, Germany, and asked Ambros about his 1948 conviction at Nuremberg for mass murder and slavery.

“That happened a very long time ago,” Ambros told the reporter. “It involved Jews. We do not think about it anymore.” – Operation Paperclip (Portions from pages 418 – 419)

Harriet A Washington’s book, “Medical Apartheid: The Dark History of Medical Experimentation on Black Americans from Colonial Times to the Present,” provided critically important knowledge and evidence about the biological and chemical weapons program in United States and one that used cholera.

“I must confirm that the structure of the [Chemical and Biological Warfare] project was based on the U.S. system. That’s where we learnt the most.” – Wouter Basson, M.D.,

“The South African bioterrorism campaign depended upon very close relationships with U.S. scientists. Despite the supposed isolation imposed upon South African scientists by the international embargoes of the 1980s until 1993, Basson and his minions could not have undertaken biological warfare without the support of the U.S. government. From 1981 until 1993, the United States supported Wouter Basson’s weaponization programs by financing close collaborations with U.S. scientists and by sponsoring Basson’s sojourns to the United States for conferences and education. For example, in 1983, Basson attended a closed Department of Defense conference on biological and chemical warfare in San Antonio. During his trial, Basson recounted his participation in a 1981 federal conference in San Antonio with army officers from the United States, West Germany, Japan, Britain, and Canada. He declared, “I must confirm that the structure of the [CBWP] project was based on the U.S. system. That’s where we learnt the most.”

Basson says he was also grateful for expert American consultants, because the CBWP was dependent upon a colorful assortment of American scientists, especially Larry Ford, M.D., of California. Ford and Basson shared strange research proclivities, acerbic racist sensibilities, and a fascination with scientific genocide. Extant medical and legal documents and the testimony of Basson’s former confederates under oath describe their shocking joint-research projects.

According to Ford’s lawyer, he was a chemical-weapons researcher for the U.S. government in the 1980. In 1987, the United States sent him to South Africa to train microbiologists at the military-run Roodeplaat Research Laboratory (RRL), a key component of South Africa’s chemical-weapons program and a front for the apartheid South African Defense Force. Ford returned often to teach RRL scientists how to produce biological agents such as anthrax and botulinum toxin for use as weapons against antiapartheid forces and against blacks in general. He also taught apartheid’s defenders how to transform innocuous objects such as doilies and tea bags into biological weapons. His seminar series, a master class for poisoners, proved popular among South African scientists, who dubbed it “Project Larry.” Lt. Gen. Lothar Neething, head of the apartheid regime’s police forensic laboratory, was in attendance. So was RRL microbiologist Dr. Mike Odendaal, who recalls, “Ford spent an entire day showing us how to contaminate ordinary items and turn them into biological weapons.” He says Ford gave them “ideas about how to infiltrate innocuous objects such as perfume or household items” and place them in close proximity to a potential target.

Ford’s expertise in the toxicology of everyday life was put to use as South African physicians busily set about eliminating the enemies of apartheid. Ford was warmly welcomed within the nation’s top echelon of medical politicians: for example, the home of former surgeon general Dr. Niels Knobel is graced by a prominently placed framed photograph of him and Ford posing with a lion that Ford had shot.”…

Goosen supervised a multitude of biological assaults on black townships, including the release of pathogens and their vectors, such as mosquitoes, to seed disease epidemics there, just as the army and the CIA had released them over Carver Village… Goosen, Basson,and their deputies investigated the use of Mandrax, an amphetamine, and Ecstasy for crowd control, infused township water supplies with treatment-resistant strains of cholera, and deployed napalm and phosphorus against blacks in Namibia and Angola during the 1980s.

Basson also ordered Goosen to suppress black reproduction surreptitiously and suggested the clandestine addition of contraceptives to townships’ drinking water. Basson stressed that this was a direct edict of the South African surgeon general.

Throughout the Cold War, Western newspapers were peppered with sporadic accounts of ethnic and racial bioweapons being developed by South Africa with U.S. assistance. U.S. news media broadly maligned all such reports as “misinformation” disseminated by the Soviet Union to embarrass the United States….

A 1998 London Sunday Times story alleged that Israel already has used South Africa’s research to develop a genetically specific weapon against arabs.” (Portions from pages 373- 378)

Cholera found in all of Yemen’s 21 governorates is as much a man-made epidemic as it was when it happened in South Africa’s black townships.
Why are they exterminating Yemen?

America and the UAE are drilling for oil and liquefied gas in the Shabwa region. Theft for industrial production needs and no different from Nazi Germany’s theft of Poland’s Oswiecem’s coal fields. Ter Meer: “There were really so many of our industrial prerequisites that one has to admit that this location, Auschwitz, was ideal industrially.”

“Hitler was IG Farben and IG Farben was Hitler,” Nuremberg prosecutor, Josiah E. DuBois, Jr.

“To the inmates of Camp I, the word “Buna” (which included “Leuna”) was more frightful than “Auschwitz” — the Farben site more terrifying than any place except a large wooded area three kilometers east of Camp I. During the first weeks of construction the workers at Camp I were routed out of bed every morning, stood roll call, ate a poor breakfast, and were marched by the SS five kilometers to the plant. Until this day of testimony, Ambros had insisted several times that disciplinary actions on the site were the responsibility of the SS. Now for some strange reason, he admitted: “I do know for sure that already in 1941 one began to fence off squares, blocks, and in these squares no SS had any further business. That was the preliminary stage for having the entire plant fenced in.” The workers had confirmed this. Once inside the plant enclosure, they found that the Farben overseers outnumbered the SS by 10 to 1…. “We struggled to carry cables, collapsing under the strain; the work was too heavy even for a nourished man.” “Once the inmates were assigned to Farben Meister, they became his slaves.” The prisoners of war, who were given easier jobs, remembered better and longer than most. “The inmates were forced to carry one-hundred C-weight bags of cement. It took four men to lift one bag and put it on the back of one man. When inmates couldn’t go along quickly enough to satisfy the Farben Meister, the Meister beat them with sticks and iron bars and punched them with his fists and kicked them. I have often seen them beaten to death with iron bars.” “When inmates first arrived at the I.G. Farben factory,” one of Ambros’ underlings had testified, “They looked reasonably well. In two or three months, they were hardly recognizable as the same people; the worst thing was the lack of food… I am not a scientist, Mr. Counselor, I would not pose as an expert on calories or grams or liters. I can merely say what I saw…. And my Czech physician friend was an expert. The Czech physician said: “The prisoners were condemned to burn up their own body weight by working.” Before construction was finished, nine out of ten punishments were meted out by the Farben plant employees. The SS at Camp I became concerned with the depletion of the labor supply. The most ironical occurrences were the repeated complaints of an SS man to his superior that a Farben foreman was beating the prisoners too often — it happened at the plant as it happened at the mine. “I did not observe anything of that kind,” Ambros said. – The Devils Chemists: 24 Conspirators of the International Farben Cartel Who Manufacture Wars by Nuremberg prosecutor, Josiah E. DuBois, Jr. portions from pages 178 – 181

“Ambros bowed as he took oath, exhibiting his sketch in all directions. He waved his counsel aside for the moment. He explained: “This tree of many branches I choose to call the Ethylene Tree to symbolize the Good and Evil in nature.”

Ethylene oxide, he went on, was the trunk which bore many branches “green with peaceful uses” and a few that were rotten with potential destruction. He pointed to lines he had drawn to cut off the rotten branches. Green branches had been his sole interest: soap for dirty soldiers, paint and cleaning agents for vehicles. “I still do not understand why I am here. The collapse promised everything but that I would be arrested.”

At Gerdorf, after those senseless investigations, the Americans had been kind enough to lend him a jeep and driver, to take him back home. Surely, if he had deserved arrest, the French at Ludwigshafen would have picked him up. He’d lived in Ludwigshafen since the mid-1920’s; people there thought he was just born for the place. If Heidelberg was the seat of chemical knowledge, Ludwigshafen was nature’s laboratory; and Ambros was the sort of man who liked earth running through his fingers. At Ludwigshafen, more productive than any other single Farben installation, were planted the synthetic seeds of every Farben product. Ludwigshafen put out the elementary compounds that became hormones and vitamins under Hoerlein at Elberfeld. At Ludwigshafen, the organic roots under careful cultivation grew their first ersatz offshoots. His “mother” was Ludwigshafen, said Ambros; but he owed a good deal, too, to his real father, a professor of agricultural chemistry, who had taken him into the laboratory before he could toddle. It was understandable that, at first sight of Oswiecem, he noted it was “predominantly agricultural terrain.”

When Bosch and Krauch hired Ambros, they got a young man with brains as well as feet in the soil. Bosch, recognizing a young excitable genius, turned him loose to study natural dyes and rosins and yeast breeding and sugar fermentation. Soon the Ethylene Tree was bearing synthetic twigs based on his studies.” – The Devils Chemists: 24 Conspirators of the International Farben Cartel Who Manufacture Wars by Nuremberg prosecutor, Josiah E. DuBois, Jr. page 170

Many branches on the tree of life will be sacrificed in order to feed the ethylene oxide tree invention of Otto Ambros. The people of Yemen are the current branch being sacrificed. Yemen is being systematically exterminated and there is nothing but silence from US media. The Holocaust in Yemen will continue until voices speak out and share the truth of what is happening to them and why.

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While I was a consultant to the Prussian Ministry of Health in Germany during 1930 – 1933, I had occasion to advise Dr. Hirtsiefer State Secretary of Health, about the deplorable condition of the soil around certain large cities, especially Essen, Dortmund, and Dusseldorf. I suggested the use of human manure, mostly wasted by canalization in place of chemical fertilizers. This was carried out along with the planting of vegetable gardens around these big cities. Composts, i.e., a mixture of dried manure from humans and animals plus straw and leaves, were used to cover these gardens in October and November and were allowed to remain through the winter. The soil was then ploughed in the spring; planting was done from four to six weeks later. Depending upon the original condition of the soil, it took several years or more to develop a fertile topsoil by this method. According to Dr. Hirtsiefer, the results were highly satisfactory, in that vegetables were obtained which were greatly superior in both quantity and quality to those previously obtained by the use of chemical fertilizers. It is interesting that no human disease was transmitted by this type of fertilizing, due, most probably, first to compost being exposed to sun, air, freezing, and snow throughout the winter, and second to the fact that most pathogenic bacteria will not survive long in a healthy soil which normally contains much antibiotic material. This is the method of the natural cycle used for over a thousand years by the farmers of the ancient Teutonic or Allemanic Empire, now known as Western Europe.
For more than 30 years Professor Czapek of Prague collected an enormous amount of information about the mineral content of the lowly potato. He found whenever artificial fertilizer was used on potatoes, there generally was a great increase in the potato crop but at the same time there was more sodium chloride and H20 and less starch and K,P, etc.; therefore, there was a greater vulnerability to many diseases in which excess NaCI and H20 play a prominent causative and dangerous part. … On a commercial fox ranch in the Harz Mountains the owner made a striking animal experiment. He used vegetables and fruits raised by organic gardening to cure foxes with lung tuberculosis after reading in a journal of my method of treating lung tuberculosis. He cured six out of seven foxes with the dietetic regime, containing among other things a great deal of K plus living tissue enzymes; he observed that the furs became extraordinarily good. He then advertised to buy sick foxes from other farms for very little, and established a large business as the low cost tuberculosis foxes regained their health and produced high quality fox furs…
We must conclude from these observations that unless the soil is cared for properly, the depleted soil with its abnormal external metabolism will bring about more and more abnormalities of our internal metabolism, resulting in serious degenerative diseases in animals and human beings. The soil needs activity–the natural cycle of growth; it needs rest; it needs protection from erosion; and finally, it needs less and less artificial fertilizer, but more and more of the use of organic waste material in the correct way, to maintain the soil’s productivity and life. Food produced in that way–we have to eat as living substances, partly fresh and partly freshly prepared, for life begets life. Organic gardening food seems to be the answer to the cancer problem.

Dr. Max Gerson Pages 183 – 185

Chapter XIII – Scientists Term Radiation A Peril to Future of Man

Chapter XXIII – Insecticides. “…spraying with modern insecticides is doing more and more damage to our food and to our bodies. I cannot emphasize too often that our nutrition is our external metabolism…. The introduction for uncontrolled general use by the public of the insecticide DDT, or chlorophenothane, and the series of even more deadly substances that followed, has no previous counterpart in history.” page 167

from CANCER RESEARCH
Hearings before a Subcommittee of the COMMITTEE ON FOREIGN RELATIONS
UNITED STATES SENATE
SEVENTY-NINTH CONGRESS
Second Session on S. 1875

A Bill to authorize and request the President to undertake to mobilize at some convenient place in the United States an adequate number of the World’s Outstanding Experts, and coordinate and utilize their services in a Supreme Effort to Discover Means of Curing and Preventing Cancer.

July 1, 2, and 3, 1946

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House Oversight and Government Reform Committee Investigation into Johnson and Johnson’s Recall of Children’s Tylenol and Other Children’s Medicines

Statement of
Joshua M. Sharfstein, M.D.
Principal Deputy Commissioner
U.S. Food and Drug Administration
Department of Health and Human Services

Before the
Committee on Oversight and Government Reform
U.S. House of Repersentatives

May 27, 2010
Introduction
Mr. Chairman and Members of the Committee, I am Joshua M. Sharfstein, M.D., Principal Deputy Commissioner, U.S. Food and Drug Administration (FDA or the Agency), which is an Agency of the Department of Health and Human Services. Thank you for the opportunity to discuss the Agency’s regulation of drug manufacturing, our oversight of McNeil Consumer Healthcare, LLC (McNeil), and lessons learned from the ongoing investigation into quality concerns at McNeil.

FDA Oversight of Drug Manufacturing
Under the Federal Food, Drug, and Cosmetic Act, FDA is charged with, among other things, ensuring that drugs marketed in the United States are safe and effective, and are manufactured in accordance with current Good Manufacturing Practice (cGMP).

The cGMP regulations for drugs contain minimum requirements for the methods, facilities, and controls used in manufacturing, processing, and packing of a drug product. The regulations are intended to ensure purity, potency, and quality of drug products, and to prevent unsafe products from reaching consumers.

Under the cGMP regulations, each manufacturer sets specifications for its own products for such factors as potency, stability and purity, and puts in place a quality system that ensures those specifications are met. Critical to the cGMP process is that a company must meet its own standards.

A violation of cGMP does not necessarily mean that a product is hazardous to the public. It does indicate, however, a breakdown in a manufacturer’s quality system and is an indication that a company needs to take effective steps to fix the problem promptly.

FDA inspects facilities to ensure compliance with cGMP standards. These inspections occur on average for domestic facilities every two to three years. We increase the frequency of inspections for facilities when warranted by past problems or by products that are difficult to manufacture or are especially high risk.

When on site, FDA inspectors identify gaps in manufacturing standards and discuss with companies how they can fix them. Firms may choose to recall products when there are cGMP violations, especially when those violations have a significant impact on product quality or safety.

For drugs, patterns of non-compliance or non-compliance that put the public’s health at risk leads to appropriate enforcement action by the Agency, including warning letters, seizures, injunctions and criminal prosecution.

Oversight of McNeil Consumer Healthcare, LLC (McNeil)
McNeil makes a variety of over-the-counter (OTC) products for the U.S. market from four manufacturing facilities in the United States and Canada. Over the last several years, FDA has had growing concerns about the quality of the company’s manufacturing process. These concerns have led to a number of unsatisfactory inspections and consumer recalls. FDA has inspected the company’s facilities with an increased frequency, and in February 2010, the Agency took the extraordinary step of convening a meeting with the management of the parent company, Johnson & Johnson, to express concern about a pattern of non-compliance.

Prior to 2009. Before 2009, FDA investigators identified several problems with cGMP compliance at facilities run by McNeil. These problems included laboratory controls, equipment cleaning processes, and a failure to investigate identified problems. The company generally fixed the specific problems, and the Agency inspected the firm regularly.

Spring/Summer 2009. At its Fort Washington facility, McNeil makes a wide variety of OTC products, including a large number of OTC liquid products for children.

In May and June 2009, FDA identified several cGMP violations, including McNeil’s failure to meet its own standard for quality in one of the ingredients in OTC liquids.

McNeil’s standard for this ingredient, known as microcrystalline cellulose, required that there be no gram negative bacteria. McNeil purchased the cellulose in partial lots that had not tested positive for this objectionable bacteria. The vendor tested other partial lots from the same large master lot and found a certain gram negative bacteria called B. cepacia. According to cGMP standards, McNeil should not have used any partial lots from this master lot.

In reviewing the situation, FDA scientists concluded that the risk to the public was remote. All of the drums used tested negative for the bacteria B. cepacia, all of the final product tested negative, and FDA agreed with the company’s assessment that this bacteria would be very unlikely to grow in the final product.

Yet, because the company had not kept to its standard, it represented a cGMP violation, and the company initiated a recall of almost eight million bottles of finished product in August 2009.

Fall 2009. At its Las Piedras, Puerto Rico, facility, McNeil makes a large number of OTC pills for the U.S. market.

In the fall of last year, FDA became aware that McNeil had received reports of products from this facility having a musty odor. Yet, McNeil had not fully investigated these reports for about a year and did not notify FDA despite the requirement that such reports be referred to the Agency within three days.

FDA inspectors urged McNeil to conduct a complete investigation, which eventually identified the source of the odor to be a chemical, called 2,4,6-Tribromoanisole or TBA, which was in the air because of a pesticide used on the wood of the pallets used to store empty medication bottles. McNeil initiated a series of recalls as the scope of the problem became clear.

The risk posed to the public by this problem included potential temporary, non-serious gastrointestinal reactions – including nausea, stomach pain, vomiting, or diarrhea. Very little is known about the chemical TBA, but in the small quantities transferred to the products, it is not thought to pose a serious risk for long-term health problems.

On January 15, 2010, FDA issued a warning letter to McNeil expressing serious concerns about the company’s control over the quality of its drugs and the company’s failure to aggressively investigate and correct quality problems. This letter identified significant violations of the cGMP regulations. FDA noted that neither upper management at Johnson & Johnson nor at McNeil assured timely investigation and resolution of the issues.

January and February 2010. In early 2010, FDA conducted focused inspections of McNeil at both the Las Piedras and Fort Washington facilities to follow up on a reported problem. The report identified a 6-year-old child who died. Prior to his death, the child had been given several products manufactured by McNeil at these facilities. FDA tested the products the child had taken for potential contamination, and all results were negative. Based on the results of the testing and the results of the inspection, FDA did not find evidence to link the products to the child’s death.

February 2010. On February 19, 2010, senior compliance staff from FDA’s Center for Drug Evaluation and Research and from FDA’s field organization met with senior officials from McNeil and its parent company, Johnson & Johnson. Attendees included the President of McNeil, the Company Group Chairman for OTC at Johnson & Johnson, as well as a number of Quality Assurance executives from both companies.

This was an extraordinary meeting. FDA requested that senior officials from Johnson & Johnson attend the meeting so they would be on notice regarding FDA’s rising concerns about whether McNeil’s corporate culture supported a robust quality system to ensure the purity, potency and safety of its products. FDA also raised concerns about Johnson & Johnson’s oversight of McNeil due to recent multiple recalls of McNeil products and recent warning letters FDA had issued to both McNeil and its parent company, Johnson & Johnson. Based on the Fort Washington and Las Piedras inspections in 2009 as well as the firm’s recent compliance history, FDA expressed its significant concern that there was a pattern of conduct including failure to report material information to FDA in a timely manner, miscalculating and/or misstating risks and benefits of their products, and reactive vs. proactive approaches to product quality problems. FDA told the company’s leadership that significant, immediate steps were needed to address issues of compliance and quality, especially in investigating product quality issues so that the company could take preventive action to avoid problems.

The Agency learned that McNeil was taking several major steps to address these issues, including implementing management reporting structure changes, hiring new managers, and engaging a third party manufacturing consultant. FDA indicated that it would continue to monitor closely and consider further action, and that it was concerned about whether the company’s corporate culture was appropriately focused on product quality issues.

April 2010. In April, FDA inspectors returned to McNeil’s Fort Washington facility. This inspection was scheduled sooner than usual due to McNeil’s recent history of compliance problems, including numerous recalls and cGMP deficiencies discovered in the June 2009 Fort Washington inspection, which had a significant impact on the scheduling of the April 2010 inspection.

Days before the inspectors arrived, McNeil shut down manufacturing because of manufacturing issues, including particulates found in a number of liquid medications. These particulates included acetaminophen, cellulose, nickel, and chromium. FDA inspectors identified a range of cGMP violations. These included the company failing to meet its own specifications for bacteria and particulates and, for one Tylenol product, the possibility of higher than expected concentrations of Tylenol per dropper.

In reviewing the situation, FDA scientists concluded that the risk posed to the public by these problems was remote. FDA did not find evidence that McNeil used raw materials that its tests found to be positive for bacterial contamination and all lots of finished product were tested by McNeil and found negative for bacterial contamination. The particulates would be expected to pass through the gastrointestinal tract. While there was a potential for higher concentrations of Tylenol per dropper, none of the final products released for sale tested with high levels. In addition, the increase in potency would not be expected to cause adverse effects.

Although the public health risk from these quality problems is low, these problems should never have occurred, and the cGMP failures at the facility that caused them were unacceptable. Following cGMP requirements assures that products are consistent in their safety and effectiveness and failure to follow those procedures undermines consumer confidence. On April 30, 2010, McNeil announced a voluntary recall of over 136 million bottles of liquid infants’ and children’s products.

Next Steps in FDA Oversight of McNeil

Based on the pattern of concerns found at McNeil’s facilities, FDA is working with the company to address its systemic quality issues. The Agency is closely monitoring the implementation of a corrective action plan developed by McNeil that includes significant enhancements to its quality system, organizational changes, and senior management oversight.

FDA will continue to investigate issues related to the Fort Washington facility including oversight related to renewal of manufacturing operations at that facility, to evaluate the facility’s suppliers, and evaluate the compliance of all other McNeil facilities. FDA will also take steps to help ensure that when the facility begins manufacturing again it will be able to produce safe products. FDA is also considering additional enforcement actions against the company for its pattern of non-compliance which may include seizure, injunction or criminal penalties.

Adverse Event Evaluation
It is understandable that many Americans, hearing about these large recalls, would wonder whether or not their children were put at risk. In assessing this question, FDA considers two basic sources of information – first, our assessment of the manufacturing problems themselves, and second, adverse event reports to the Agency.

As I discussed earlier, FDA analyzed the various manufacturing problems. Based on the circumstances in each case, our experts believe the risk for any child in the United States was remote.

FDA has also looked at adverse events reported to the Agency. FDA receives these reports and often requests and reviews medical records, coroner’s reports, and other supplementary data sources.

When we have adequate information about a case, the Agency reviews these reports to determine what role, if any, the medication played in the development of an adverse event. We can find that the medication likely had no role in the adverse event, that the medication’s activity as a drug could have caused a serious side effect, or that a quality problem may have contributed to the outcome.

All drugs have side effects, and some of the McNeil reports may reflect the side effects of OTC medications. Other reports appear unrelated to the medications.

So far, FDA has no cases with evidence that a product quality issue contributed to a significant adverse health outcome. We are continuing to receive information about certain cases and we will update the public and the Committee should our assessment change.

Lessons Learned
Every investigation presents an opportunity for FDA to improve our effectiveness in protecting the public health. One lesson to be drawn from the McNeil story is that it is important for the Agency to even more fully consider the corporate structure when investigating and enforcing the law. FDA will be developing new procedures to use what we learn at one facility in guiding our inspections of other facilities run by the same company.

FDA is also using these events as part of an ongoing review of our recall process. FDA has already made significant changes to its approach to recalls when there are urgent, life-threatening product quality concerns. For example, in recent months, FDA has moved aggressively to support several urgent food recalls. FDA is now looking at our process for clear expectations and standards with respect to other types of recalls, such as those undertaken by McNeil.

We will continue to work with Congress to secure additional authorities that could assist us in assuring product quality and acting more quickly when product quality issues occur.
FDA will also be considering enforcement actions in this case as part of the Agency’s ongoing changes in enforcement. FDA Commissioner Dr. Margaret Hamburg has called for FDA’s enforcement to be “vigilant, strategic, quick, and visible.” A range of activities are underway at the Agency to bring this vision to reality, including strengthening our criminal enforcement of FDA’s laws.

As we continue these efforts, as well as our other regulatory work, we will focus on entire companies and their systems in addition to focusing on specific violations, individuals, and sites, much as we are doing in the McNeil situation.

Conclusion
Thank you for the opportunity to explain FDA’s oversight of drug manufacturing and our engagement with McNeil. I look forward to your questions.

“Gentle on little tummies.. When it comes to reducing fever or relieving pain in infants, INFANTS’ TYLENOL® has been the brand recommended most by pediatricians for the last 20 years. INFANTS’ TYLENOL® works differently than other pain and fever medicines. It also won’t upset little stomachs…. anhydrous citric acid, butylparaben, D&C red no. 33, FD&C Blue no.1, flavors, glycerin, high fructose corn syrup, microcrystalline cellulose and carboxymethylcellulose sodium, propylene glycol, purified water, sodium benzoate, sorbitol solution, SUCRALOSE, xanthan gum.”

The Search For Sweet by Burkhard Bilger for The New Yorker – May 22, 2006

“The substance in the flask seemed to have all the makings of an excellent insecticide. It was a fine crystaline powder and its molecules were full of chlorine atoms, like DDT. ..by taking an eye-dropper full of sulfuryl chloride – a highly toxic chemical – and adding it to a sugar solution, one drop at a time. In the violent reaction that followed, a wholly new compound was born: 1′, 4,6,6′-tetrachloro-1′,4,6,6′-tetra-deoxygalactosucrose. “It isn’t of any use as an insecticide,” Hough told me recently, “That was tested.” But it has proven useful as a food. In its pure form, it is known as sucralose. When mixed with fillers and sold in bright yellow sachets, it’s known as Splenda, the best-selling artificial sweetener in America.”

Sucralose was declared safe by the Food and Drug Administration in 1998, but most of the taste researchers I talked to won’t eat it. “I look at that structure and I have an irrational fear of it,” one of them said.”

http://archives.newyorker.com/?i=2006-05-22#folio=040

J Toxicol Environ Health A. 2008;71(21):1415-29. doi: 10.1080/15287390802328630.
Splenda alters gut microflora and increases intestinal p-glycoprotein and cytochrome p-450 in male rats.
Abou-Donia MB1, El-Masry EM, Abdel-Rahman AA, McLendon RE, Schiffman SS.
Author information

Abstract
Splenda is comprised of the high-potency artificial sweetener sucralose (1.1%) and the fillers maltodextrin and glucose. Splenda was administered by oral gavage at 100, 300, 500, or 1000 mg/kg to male Sprague-Dawley rats for 12-wk, during which fecal samples were collected weekly for bacterial analysis and measurement of fecal pH. After 12-wk, half of the animals from each treatment group were sacrificed to determine the intestinal expression of the membrane efflux transporter P-glycoprotein (P-gp) and the cytochrome P-450 (CYP) metabolism system by Western blot. The remaining animals were allowed to recover for an additional 12-wk, and further assessments of fecal microflora, fecal pH, and expression of P-gp and CYP were determined. At the end of the 12-wk treatment period, the numbers of total anaerobes, bifidobacteria, lactobacilli, Bacteroides, clostridia, and total aerobic bacteria were significantly decreased; however, there was no significant treatment effect on enterobacteria. Splenda also increased fecal pH and enhanced the expression of P-gp by 2.43-fold, CYP3A4 by 2.51-fold, and CYP2D1 by 3.49-fold. Following the 12-wk recovery period, only the total anaerobes and bifidobacteria remained significantly depressed, whereas pH values, P-gp, and CYP3A4 and CYP2D1 remained elevated. These changes occurred at Splenda dosages that contained sucralose at 1.1-11 mg/kg (the US FDA Acceptable Daily Intake for sucralose is 5 mg/kg). Evidence indicates that a 12-wk administration of Splenda exerted numerous adverse effects, including (1) reduction in beneficial fecal microflora, (2) increased fecal pH, and (3) enhanced expression levels of P-gp, CYP3A4, and CYP2D1, which are known to limit the bioavailability of orally administered drugs.

Splenda: The Artificial Sweetener that Explodes Internally
By: Shane Ellison, MS for The People’s Chemist

“Splenda contains the drug sucralose. This chemical is 600 times sweeter than sugar. To make sucralose, chlorine is used. Chlorine has a split personality. It can be harmless or it can be life threatening.
In combo with sodium, chlorine forms a harmless “ionic bond” to yield table salt. Sucralose makers often highlight this worthless fact to defend its’ safety. Apparently, they missed the second day of Chemistry 101 – the day they teach “covalent” bonds.
When used with carbon, the chlorine atom in sucralose forms a “covalent” bond. The end result is the historically deadly “organochlorine” or simply: a Really-Nasty Form of Chlorine (RNFOC).
Unlike ionic bonds, covalently bound chlorine atoms are a big no-no for the human body. They yield insecticides, pesticides, and herbicides – not something you want in the lunch box of your precious child. It’s therefore no surprise that the originators of sucralose, chemists Hough and Phadnis, were attempting to design new insecticides when they discovered it! It wasn’t until the young Phadnis accidentally tasted his new “insecticide” that he learned it was sweet. And because sugars are more profitable than insecticides, the whole insecticide idea got canned and a new sweetener called Splenda got packaged.
To hide its dirty origin, Splenda pushers assert that sucralose is “made from sugar so it tastes like sugar.” Sucralose is as close to sugar as Windex is to ocean water.”

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“Our Stolen Future,” by Theo Colborn, Dianne Dumanoski, and John Peterson Myers.
Hand-Me-Down Poisons Excerpt

Gilbertson had given Colborn complete access to his meticulously organized collection of material on each animal species that breeds in the Great Lakes basin–data that he had gathered over the years and arranged in chronological order in three-ring binders. Colborn was awed by the elegance of the effort and by the years of dedication and scholarly consideration that it reflected. With a sense of history, Gilbertson had gone to great lengths to collect papers and studies dating back a half century or more–literature documenting that the problems seen today in the birds and wildlife along the lakes had not been reported before World War II. In the bald eagle file, she found evidence of parallel declines in the postwar period in the bald eagle in North America and in its European cousin, the white-tailed sea eagle, along with a collection of reports detailing the concentrations of synthetic chemical contaminants found in both species. Photocopies from Gilbertson’s archive had greatly enriched Colborn’s files, but their conversations, during which Gilbertson generously shared his broad experience, had proven even more valuable.

Over lunch in the Canadian Wildlife Service cafeteria, Colborn, Gilbertson, and Fox had discussed the wildlife evidence contradicting the frequent claims that the lakes had been cleaned up. The two Canadians shared the conviction the wildlife work had likely implications for human health and constituted a warning humans ought to heed. In her survey of the scientific literature, Colborn had been fascinated by some of Fox’s work, which reported evidence of behavioral changes in wildlife as well as signs of physical damage.

In herring gull colonies, particularly in highly polluted areas of Lakes Ontario and Michigan, Fox and his colleagues had found nests with twice the normal number of eggs–a sign that the birds occupying the nests were two females instead of the expected male-female pair. The phenomenon, which persisted in some areas, had been particularly prevalent in the mid to late 1970s. During this period, Fox had collected and preserved seventeen near-term embryos and newly hatched chicks from the affected colonies in hopes that he might eventually discover what was causing this unusual behavior and other reproduction problems.

A few years later, Fox encountered a scientist who might help him find the answer. Michael Fry, a wildlife toxicologist at the University of California at Davis, had investigated how the pesticide DDT and other synthetic chemicals disrupt the sexual development of birds after hearing reports of nests with female pairs in western gull colonies in southern California. While some looked for an evolutionary explanation for the phenomenon, Fry had suspected contamination. Reports in scientific literature indicated that a number of synthetic chemicals, including the pesticide DDT, could somehow act like the female hormone estrogen.

To test his theory, Fry had injected eggs taken from western gull and California gull colonies in relatively uncontaminated areas with four substances–two forms of DDT; DDE, the breakdown product of DDT; and methoxychlor, another synthetic pesticide that had also been reported to act like the hormone estrogen. The experiment showed that the levels of DDT reported in contaminated areas would disrupt the sexual development of male birds. Fry noted a feminization of the males’ reproductive tracts, evident by the presence of typically female cell types in the testicles or, in cases of higher doses, by the presence of an oviduct, the egg-laying canal normally found in females. Despite all this internal disruption, the chicks had no visible defects and looked completely normal.

As soon as he could make arrangements, Fox shipped the preserved embryos and chicks off to Fry in California. In his examination of the birds’ reproductive tracts, Fry found that five of the seven males were significantly feminized and two had visibly abnormal sex organs. Five of the nine females showed significant signs of disrupted development as well, including the presence of two egg-laying canals instead of the one that is normal in gulls. Such disruption, Fry noted, could indicate that the birds had been exposed to chemicals that acted like the female hormone estrogen.

Earlier experiments by other researchers had shown that exposing male birds to estrogen during development affects the brain as well as the reproductive tract and permanently suppresses sexual behavior. When chicken and Japanese quail eggs received estrogen injections, the males that hatched never crowed, strutted, or exhibited mating behavior as adults.

Taken together, the evidence in the Great Lakes suggested that the females were nesting together because of a shortage of males, which might be absent because they were disinterested in mating or incapable of reproducing. Though most eggs in these same sex nests were infertile, these females sometimes managed to mate with an already paired male and hatch a chick. The female pairs appeared to be an effort to make the best of a bad situation.

Fox and others had noticed other behavioral abnormalities as well, particularly in birds that had high levels of chemical contamination. In Lake Ontario colonies, the birds showed aberrant parental behavior, including less inclination to defend their nests or sit on their eggs. In unsuccessful nests, the incubating eggs were unattended for three times as long as in the nests where birds successfully produced offspring. A study comparing reproduction in Forster’s terns nesting in clean and contaminated areas reported that nest abandonment and egg disappearance, often due to theft by predators, was substantial in the contaminated area on Lake Michigan but virtually nonexistent in the clean colony on a smaller lake in Wisconsin. Parental inattentiveness clearly diminished the chances that the eggs would hatch and the chicks would survive.

What Colborn remembered afterward about the conversation was how cautious they had all been. Despite the shared view that wildlife findings had implications for humans, no one wanted to acknowledge the unspoken question hanging in the air. No one dared ask whether synthetic chemicals might be having similar disrupting effects on human behavior. Those were treacherous waters they all preferred to avoid.

pages 20 – 22

For additional information – http://www.ourstolenfuture.org/

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I have stumbled upon one factor that has been overlooked in Autism research and infant and children’s health. Pediatricians often recommend giving infants and children Tylenol and Mortin (for infants over 6 months) for pain management prior or just after they’ve received a vaccine. What public and health care professionals do not know is that there is an excipient in the infant and children Tylenol and some of the Motrin formulations that contains a chlorocarbon (or organochloride) utilized as the sweetening agent.


To access Children’s Tylenol ingredient list click here.

Sucralose or what is commonly known as Splenda is the organochloride or chlorocarbon utilized in the suspension fluids. The invention of sucralose or Splenda was documented in the New Yorker article, “The Search For Sweet,” by Burkhard Bilger – May 22, 2006.

The substance in the flask seemed to have all the makings of an excellent insecticide. It was a fine crystaline powder and its molecules were full of chlorine atoms, like DDT. ..by taking an eye-dropper full of sulfuryl chloride – a highly toxic chemical – and adding it to a sugar solution, one drop at a time. In the violent reaction that followed, a wholly new compound was born: 1′, 4,6,6′-tetrachloro-1′,4,6,6′-tetra-deoxygalactosucrose. “It isn’t of any use as an insecticide,” Hough told me recently, “That was tested.” But it has proven useful as a food. In its pure form, it is known as sucralose. When mixed with fillers and sold in bright yellow sachets, it’s known as Splenda, the best-selling artificial sweetener in America.”

Sucralose was declared safe by the Food and Drug Administration in 1998, but most of the taste researchers I talked to won’t eat it. “I look at that structure and I have an irrational fear of it,” one of them said.

To access this article view on the link below. The New Yorker does charge a small fee to access this archived issue.


The Search For Sweet by Burkhard Bilger for The New Yorker – May 22, 2006


THE LETHAL SCIENCE OF SPLENDA, A POISONOUS CHLOROCARBON by James Bowen, M.D.

James Bowen explains the impacts of Splenda (sucralose).

“Splenda/sucralose is simply chlorinated sugar; a chlorocarbon. Common chlorocarbons include carbon tetrachloride, trichlorethelene and methylene chloride, all deadly. Chlorine is nature’s Doberman attack dog, a highly excitable, ferocious atomic element employed as a biocide in bleach, disinfectants, insecticide, WWI poison gas and hydrochloric acid.

“Sucralose is a molecule of sugar chemically manipulated to surrender three hydroxyl groups (hydrogen + oxygen) and replace them with three chlorine atoms. Natural sugar is a hydrocarbon built around 12 carbon atoms. When turned into Splenda it becomes a chlorocarbon, in the family of Chlorodane, Lindane and DDT.

“It is logical to ask why table salt, which also contains chlorine, is safe while Splenda/sucralose is toxic? Because salt isn’t a chlorocarbon. When molecular chemistry binds sodium to chlorine to make salt carbon isn’t included. Sucralose and salt are as different as oil and water.

“Unlike sodium chloride, chlorocarbons are never nutritionally compatible with our metabolic processes and are wholly incompatible with normal human metabolic functioning. When chlorine is chemically reacted into carbon-structured organic compounds to make chlorocarbons, the carbon and chlorine atoms bind to each other by mutually sharing electrons in their outer shells. This arrangement adversely affects human metabolism because our mitochondrial and cellular enzyme systems are designed to completely utilize organic molecules containing carbon, hydrogen, oxygen, nitrogen, and other compatible nutritional elements.

“By this process chlorocarbons such as sucralose deliver chlorine directly into our cells through normal metabolization. This makes them effective insecticides and preservatives. Preservatives must kill anything alive to prevent bacterial decomposition.”

Dr. Bowen believes ingested chlorocarbon damage continues with the formation of other toxins: “Any chlorocarbons not directly excreted from the body intact can cause immense damage to the processes of human metabolism and, eventually, our internal organs. The liver is a detoxification organ which deals with ingested poisons. Chlorocarbons damage the hepatocytes, the liver’s metabolic cells, and destroy them.

In test animals Splenda produced swollen livers, as do all chlorocarbon poisons, and also calcified the kidneys of test animals in toxicity studies. The brain and nervous system are highly subject to metabolic toxicities and solvency damages by these chemicals. Their high solvency attacks the human nervous system and many other body systems including genetics and the immune function. Thus, chlorocarbon poisoning can cause cancer, birth defects, and immune system destruction. These are well known effects of Dioxin and PCBs which are known deadly chlorocarbons.”

Dr. Bowen continues: “Just like aspartame, which achieved marketplace approval by the Food and Drug Administration when animal studies clearly demonstrated its toxicity, sucralose also failed in clinical trials with animals. Aspartame created brain tumors in rats. Sucralose has been found to shrink thymus glands (the biological seat of immunity) and produce liver inflammation in rats and mice.

“In the coming months we can expect to see a river of media hype expounding the virtues of Splenda/sucralose. We should not be fooled again into accepting the safety of a toxic chemical on the blessing of the FDA and saturation advertising. In terms of potential long-term human toxicity we should regard sucralose with its chemical cousin DDT, the insecticide now outlawed because of its horrendous long term toxicities at even minute trace levels in human, avian, and mammalian tissues.

Researchers have known for a long time that chlorinated compounds impact liver functionality. Rachel Carson discussed chlorinated compounds in Silent Spring. She also discusses Methoxychlor, another organochlorine once used as an insecticide, and it’s toxicity when combined with other chlorinated compounds like DDT.

One of the most significant facts about the chlorinated hydrocarbon insecticides is their effect on the liver. Of all the organs in the body the liver is most extraordinary. In its versatility and in the indispensable nature of its functions it has no equal. It presides over so many vital activities that even the slightest damage is fraught with serious consequences. Not only does it provide bile for the digestion of fats, but because of its location and the special circulatory pathways that converge upon it the liver receives blood directly from the digestive tract and is deeply involved in the metabolism of all the principal foodstuffs. It stores sugar in the form of glycogen and releases it as glucose in carefully measured quantities to keep the blood sugar at a normal level. It builds body proteins, including some essential elements of blood plasma concerned with blood-clotting. It maintains cholesterol at its proper level in the blood plasma, and inactivates the male and female hormones when they reach excessive levels. It is a storehouse of many vitamins, some of which in turn contribute to its own proper functioning.

Without a normally functioning liver the body would be disarmed–defenseless against the great variety of poisons that continually invade it. Some of these are normal by-products of metabolism, which the liver swiftly and efficiently makes harmless by withdrawing their nitrogen. But poisons that have no normal place in the body may also be detoxified. The “harmless” insecticides malathion and methoxychlor are less poisonous than their relatives only because a liver enzyme deals with them, altering their molecules in such a way that their capacity for harm is lessened. In similar ways the liver deals with the majority of the toxic materials to which we are exposed.

Our line of defense against invading poisons or poisons from within is now weakened and crumbling. A liver damaged by pesticides in not only incapable of protecting us from poisons, the whole range of its activities may be interfered with. Not only are the consequences far-reaching, but because of their variety and the fact that they may not immediately appear they may not be attributed to their true cause…..

The effect of a chemical of supposedly innocuous nature can be drastically changed by the action of another; one of the best examples is a close relative of DDT called methoxychlor (Actually, methoxychlor may not be as free from dangerous qualities as it is generally said to be, for recent work on experimental animals shows a direct action on the uterus and a blocking effect on some of the powerful pituitary hormones–reminding us again that these are chemicals with enormous biological effect. Other work shows that methoxychlor has a potential ability to damage the kidneys.) Because it is not stored to any great extent when given alone, we are told that methoxychlor is a safe chemical. But this is not necessarily true. If the liver has been damaged by another agent, methoxychlor is stored in the body at 100 times its normal rate, and will then imitate the effects of DDT with long-lasting effects on the nervous system. Yet the liver damage that brings this about might be so slight as to pass unnoticed. It might have been the result of any number of commonplace situations–using another insecticide, using a cleaning fluid containing carbon tetrachloride, or taking one of the so-called tranquilizing drugs, a number (but not all) of which are chlorinated hydrocarbons and possess power to damage the liver.

This raises very serious questions. Infant and children’s pharmaceutical excipients, inactives, or inerts (Take your pick on the term) need serious review. The Johnson & Johnson McNeil Fort Washington Facility is now closed. The FDA inspection review showed chronic failures in quality and consistency of the oral suspension formulations. This is the same facility where they make sucralose and utilized it in their infant and children’s Tylenol and Motrin formulations. Johnson & Johnson’s McNeil failed to understand the potential implications of utilizing a chlorocarbon (or organochloride) as a sweetener in infant and children’s pharmaceuticals. Parents give their infants and children Tylenol and Motrin products to help relieve their pain and suffering not knowing that something in that product may have serious long term health consequences. Has Splenda or sucralose ever been tested for its synergistic properties? Could sucralose impair liver functionality and cause other poisons or toxins to be absorbed at an accelerated rate? Those are the questions that need immediate answers.

The FDA inspection report is deeply disturbing in light of this information.

Observation 3
Control procedures fail to include adequacy of mixing to assure uniformity and homogeneity.

Control procedures used did not validate the manufacturing processes that caused variability in the characteristics of the drug product. For examples, the agitation speeds and time to reach [Blacked out] in the hold tank during processing of the [blacked out] super potent batches that failed APAP (end of run) assays, [blacked out] released batches, and the demonstration batch. The firm did not demonstrate the adequacy of mixing to assure uniformity and homogeneity for Infant’s Dye-Free Tylenol Suspension Drops, Formula [blacked out] using a [blacked out] batch in a [blacked out] hold tank. Agitation and tank levels with [blacked out] the amount of liquid) in a [blacked out] hold tank were evaluated with one demonstration bulk batch, lot ]blacked out] packaged as lot [blacked out] The [blacked out] batches into [blacked out] hold tanks used [blacked out] and the agitator was shut off at [blacked out] using the weight of [blacked out] for the [blacked out] batch in a [blacked out] hold tank. With the [blacked out] super potent batches, APAP concentrated at the end run when the agitator was shut off at [blacked out] in the tank).

To review the complete inspection report click on the link below to review the PDF.


Food & Drug Administration Facility Inspection Results for McNeil Consumer Healthcare, Division of McNeil-PPC, Inc.

The inspection results are also available here at this site.
https://renchemista.wordpress.com/2010/07/13/fda-facility-inspection-results-for-mcneil-ppc-fort-washington-pa-4192010-4302010-childrens-tylenol-motrin-recalls/

J Toxicol Environ Health A. 2008;71(21):1415-29. doi: 10.1080/15287390802328630.
Splenda alters gut microflora and increases intestinal p-glycoprotein and cytochrome p-450 in male rats.
Abou-Donia MB1, El-Masry EM, Abdel-Rahman AA, McLendon RE, Schiffman SS.
Author information

Abstract
Splenda is comprised of the high-potency artificial sweetener sucralose (1.1%) and the fillers maltodextrin and glucose. Splenda was administered by oral gavage at 100, 300, 500, or 1000 mg/kg to male Sprague-Dawley rats for 12-wk, during which fecal samples were collected weekly for bacterial analysis and measurement of fecal pH. After 12-wk, half of the animals from each treatment group were sacrificed to determine the intestinal expression of the membrane efflux transporter P-glycoprotein (P-gp) and the cytochrome P-450 (CYP) metabolism system by Western blot. The remaining animals were allowed to recover for an additional 12-wk, and further assessments of fecal microflora, fecal pH, and expression of P-gp and CYP were determined. At the end of the 12-wk treatment period, the numbers of total anaerobes, bifidobacteria, lactobacilli, Bacteroides, clostridia, and total aerobic bacteria were significantly decreased; however, there was no significant treatment effect on enterobacteria. Splenda also increased fecal pH and enhanced the expression of P-gp by 2.43-fold, CYP3A4 by 2.51-fold, and CYP2D1 by 3.49-fold. Following the 12-wk recovery period, only the total anaerobes and bifidobacteria remained significantly depressed, whereas pH values, P-gp, and CYP3A4 and CYP2D1 remained elevated. These changes occurred at Splenda dosages that contained sucralose at 1.1-11 mg/kg (the US FDA Acceptable Daily Intake for sucralose is 5 mg/kg). Evidence indicates that a 12-wk administration of Splenda exerted numerous adverse effects, including (1) reduction in beneficial fecal microflora, (2) increased fecal pH, and (3) enhanced expression levels of P-gp, CYP3A4, and CYP2D1, which are known to limit the bioavailability of orally administered drugs.

http://www.ncbi.nlm.nih.gov/pubmed/18800291

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Liver Functioning & Chemical Synergies

An Excerpt from Silent Spring by Rachel Carson

One of the most significant facts about the chlorinated hydrocarbon insecticides is their effect on the liver. Of all the organs in the body the liver is most extraordinary. In its versatility and in the indispensable nature of its functions it has no equal. It presides over so many vital activities that even the slightest damage is fraught with serious consequences. Not only does it provide bile for the digestion of fats, but because of its location and the special circulatory pathways that converge upon it the liver receives blood directly from the digestive tract and is deeply involved in the metabolism of all the principal foodstuffs. It stores sugar in the form of glycogen and releases it as glucose in carefully measured quantities to keep the blood sugar at a normal level. It builds body proteins, including some essential elements of blood plasma concerned with blood-clotting. It maintains cholesterol at its proper level in the blood plasma, and inactivates the male and female hormones when they reach excessive levels. It is a storehouse of many vitamins, some of which in turn contribute to its own proper functioning.

Without a normally functioning liver the body would be disarmed–defenseless against the great variety of poisons that continually invade it. Some of these are normal by-products of metabolism, which the liver swiftly and efficiently makes harmless by withdrawing their nitrogen. But poisons that have no normal place in the body may also be detoxified. The “harmless” insecticides malathion and methoxychlor are less poisonous than their relatives only because a liver enzyme deals with them, altering their molecules in such a way that their capacity for harm is lessened. In similar ways the liver deals with the majority of the toxic materials to which we are exposed.

Our line of defense against invading poisons or poisons from within is now weakened and crumbling. A liver damaged by pesticides is not only incapable of protecting us from poisons, the whole range of its activities may be interfered with. Not only are the consequences far-reaching, but because of their variety and the fact that they may not immediately appear they may not be attributed to their true cause.

In connection with the nearly universal use of insecticides that are liver poisons, it is interesting to note the sharp rise in hepatitis that began during the 1950’s and is continuing a fluctuating climb. Cirrhosis also is said to be increasing. While it is admittedly difficult, in dealing with human beings rather than laboratory animals, to “prove” that cause A produces effect B, plain common sense suggests that the relation between a soaring rate of liver disease and the prevalence of liver poisons in the environment is no coincidence. Whether or not the chlorinated hydrocarbons are the primary cause, it seems hardly sensible under the circumstances to expose ourselves to poisons that have a proven ability to damage the liver and so presumably to make it less resistant to disease.

Both major types of insecticides, the chlorinated hydrocarbons and the organic phosphates, directly affect the nervous system, although in somewhat different ways. This has been made clear by an infinite number of experiments on animals and by observations on human subjects as well. As for DDT, the first of the new organic insecticides to be widely used, its action is primarily on the central nervous system of man; the cerebellum and the higher motor cortex are thought to be the areas chiefly affected. Abnormal sensations as of prickling, burning, or itching, as well as tremors or even convulsions may follow exposure to appreciable amounts, according to a standard textbook of toxicology.

There is interaction even between the two major groups of insecticides usually thought to be completely distinct in their action. The power of the organic phosphates, those poisoners of the nerve-protective enzyme cholinesterase, may become greater if the body has first been exposed to a chlorinated hydrocarbon which injures the liver. This is because, when liver function is disturbed, the cholinesterase level drops below normal. The added depressive effect of the organic phosphate may then be enough to precipitate acute symptoms. And as we have seen, pairs of the organic phosphates themselves may interact in such a way as to increase their toxicity a hundredfold. Or the organic phosphates may interact with various drugs, or with synthetic materials, food additives–who can say what else of the infinite number of man-made substances that now pervade our world.

The effect of a chemical of supposedly innocuous nature can be drastically changed by the action of another; one of the best examples is a close relative of DDT called methoxychlor (Actually, methoxychlor may not be as free from dangerous qualities as it is generally said to be, for recent work on experimental animals shows a direct action on the uterus and a blocking effect on some of the powerful pituitary hormones–reminding us again that these are chemicals with enormous biological effect. Other work shows that methoxychlor has a potential ability to damage the kidneys.) Because it is not stored to any great extent when given alone, we are told that methoxychlor is a safe chemical. But this is not necessarily true. If the liver has been damaged by another agent, methoxychlor is stored in the body at 100 times its normal rate, and will then imitate the effects of DDT with long-lasting effects on the nervous system. Yet the liver damage that brings this about might be so slight as to pass unnoticed. It might have been the result of any number of commonplace situations–using another insecticide, using a cleaning fluid containing carbon tetrachloride, or taking one of the so-called tranquilizing drugs, a number (but not all) of which are chlorinated hydrocarbons and possess power to damage the liver.

Damage to the central nervous system is not confined to acute poisoning; there may also be delayed effects from exposure. Long-lasting damage to brain or nerves has been reported for methoxychlor and others. Dieldrin, besides its immediate consequences, can have long delayed effects ranging from “loss of memory, insomnia, and nightmares to mania.” Lindane, according to medical findings is stored in significant amounts in the brain and functioning liver tissue may induce “profound and long lasting effects on the central nervous system.” Yet this chemical, a form of benzene hexachloride, is much used in vaporizers, devices that pour a stream of volatilized insecticide into homes, offices, restaurants.

The organic phosphates, usually considered only in relation to their more violent manifestations in acute poisoning, also have the power to produce lasting physical damage to nerve tissues and, according to recent findings, to induce mental disorders. Various cases of delayed paralysis have followed use of one or another of these insecticides. A bizarre happening in the United States during the prohibition era about 1930 was an omen of things to come. It was caused not by an insecticide but by a substance belonging chemically to the same group as the organic phosphate insecticides. During that period some medicinal substances were being pressed into service as substitutes for liquor, being exempt from the prohibition law. One of these was Jamaica ginger. But the United States Pharmacopia product was expensive, and bootleggers conceived the idea of making a substitute Jamaica ginger. They succeeded so well that their spurious product responded to the appropriate chemical tests and deceived the government chemists. To give their false ginger the necessary tang they introduced a chemical known as triorthocresyl phosphate. This chemical, like parathion and its relatives, destroys the protective enzyme cholinesterase. As a consequence of drinking the bootleggers’ product some 15,000 people developed a permanently crippling type of paralysis of the leg muscles, a condition now called “ginger paralysis.” The paralysis was accompanied by destruction of nerve sheaths and by degeneration of the cells of the anterior horns of the spinal chord.

About two decades later various other organic phosphates came into use as insecticides, as we have seen, and soon cases reminiscent of the ginger paralysis episode began to occur. One was a greenhouse worker in Germany who became paralyzed several months after experiencing mild symptoms of poisoning on a few occasions after using parathion. Then a group of three chemical plant workers developed acute poisoning from exposure to other insecticides in this group. They recovered under treatment, but ten days later two of them developed muscular weakness in the legs. This persisted for 10 months in one; the other, a young woman chemist, was more severely affected, with paralysis in both legs and some involvement of the hands and arms. Two years later when her case was reported in a medical journal she was still unable to walk.

The insecticide responsible for these cases has been withdrawn from the market, but some of those now in use may be capable of harm. Malathion (beloved by gardeners) has induced severe muscular weakness in experiments on chickens. This was attended (as in ginger paralysis) by destruction of the sheaths of the sciatic and spinal nerves.

All these consequences of organic phosphate poisoning, if survived, may be a prelude to worse. In view of the severe damage they inflict upon the nervous system, it was perhaps inevitable that these insecticides would eventually be linked with mental disease. That link has recently been supplied by investigators at the University of Melbourne and Prince Henry’s Hospital in Melbourne, who reported on 16 cases of mental disease. All had a history of prolonged exposure to organic phosphorus insecticides. Three were scientists checking the efficacy of sprays; 8 worked in greenhouses; 5 were farm workers. Their symptoms ranged from impairment of memory to schizophrenic and depressive reactions. All had normal medical histories before the chemicals they were using boomeranged and struck them down.

Echoes of this sort of thing are to be found, as we have seen, widely scattered throughout medical literature, sometimes involving chlorinated hydrocarbons, sometimes the organic phosphates. Confusion, delusions, loss of memory, mania–a heavy price to pay for the temporary destruction of a few insects, but a price that will continue to be exacted as long as we insist upon using chemicals that strike directly at the nervous system.

Portions taken from pages 191 – 198

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